Cryo-electron microscopy structures of VCP/p97 reveal a new mechanism of oligomerization regulation
Summary: VCP/p97 is an evolutionarily conserved AAA+ ATPase important for cellular homeostasis.Previous studies suggest that VCP predominantly exists as a homohexamer.Here, we performed structural and biochemical characterization of VCP dodecamer, an gtech brush bar understudied state of VCP.The structure revealed an apo nucleotide status that has